For most guys, PrEP is very safe to take, and very easy on the system. In fact, most of us won’t experience any side effects at all, and for those who do experience side effects, they tend to be minor (like nausea) and temporary. Experiences of poz guys who take HIV treatment reflect that this med is safe and light on side-effects. In fact, this is one of the primary reasons Truvada was selected as the first drug for major PrEP research: it was already being taken by a large number of gay guys for HIV treatment.
For most of us, PrEP has one very common side effect: peace of mind!